Abstract Background: Association between periodontal disease and dyslipidemia was recently reported in healthy adults. However, a systematic evaluation of concomitant periodontal diseases and lipid profile was not carried out in juvenile dermatomyositis (JDM). A cross-section study was performed in 25 JDM patients and 25 healthy controls, assessing demographic data, periodontal evaluation, fasting lipoproteins and anti-lipoprotein lipase antibodies. Disease parameters, laboratorial tests and treatment were also evaluated in JDM patients. Results: The mean current age was similar in patients and controls (11.5 ± 3.75 vs. 11.2 ± 2.58 years, p = 0.703). Regarding lipid profile, the median triglycerides [80(31–340) vs. 61(19–182)mg/dL, p = 0.011] and VLDL[16(6–68) vs. 13(4–36)mg/dL,p = 0.020] were significantly higher in JDM patients versus controls. Gingival vasculopathy pattern was significantly higher in the former group (60% vs. 0%, p = 0.0001), as well as the median of gingival bleeding index (GBI) [24.1(4.2–69.4) vs. 11.1(0–66.6)%,p = 0.001] and probing pocket depth (PPD) [1.7(0.6–2.4) vs.1.4(0–2.12) mm,p = 0.006]. Comparison between JDM patients with and without dyslipidemia revealed that the median of dental plaque index (PI) [100(26.7–100) vs. 59(25–100)%,p = 0.022], PPD[1.9(0.6–2.4) vs. 1.4(1.2–1.8)mm,p = 0.024] and clinical attachment level (CAL) [1.31(0.7–1.7) vs. 0.8(0.6–1.7)mm,p = 0.005] were significantly higher in patients with dyslipidemia. Further analysis between JDM patients with and without gingivitis revealed that the median of current age [12.4 (8.3–18.4) vs. 9.2 (5.5–17.5) years, p = 0.034] and disease duration [7.09 ± 3.07 vs. 3.95 ± 2.1 years, p = 0.008] were significantly higher in the former group. Conclusion: Our study showed that gingival inflammation seems to be related to dyslipidemia in JDM patients, suggesting underlying mechanisms for both complications.

The aim of this research is to determine the impact of periodontal treatment on the quality of life of patients with concomitant chronic headache or facial pain and periodontal disease. Thirty-eight consecutive patients with chronic periodontal disease were divided according to the presence of chronic craniofacial pain (CFP):Study Group-with CFP and Control Group-without CFP. They were evaluated with the Clinical protocol of the Orofacial Pain Clinic, the WHOQOL-bref and the McGill Pain Questionnaire. All patients received periodontal treatment. The Study Group presented worst quality of life than the Control Group. Nevertheless, the Study Group showed trend improvement in the psychological score (p=0.06) and affective descriptors at the McGill Pain Questionnaire improved (p=0.014) after periodontal treatment. There were no significant changes in quality of life from pre- to post- operatory evaluations in both groups (p>0.05). We conclued that chronic craniofacial pain sufferers presented worst score at physical and psychological domain of quality of life, however there was an improvement in their psychological state 180 days after periodontal treatment.

El objetivo fue determinar el impacto del tratamiento periodontal sobre la calidad de vida de los pacientes con cefalea crónica concomitante o dolor facial y enfermedad periodontal. Treinta y ocho pacientes consecutivos con enfermedad periodontal crónica fueron divididos de acuerdo a la presencia de dolor craneofacial crónico (CFC); grupo de estudio con CFC y el grupo control, sin CFC. Fueron evaluados con el protocolo clínico de la Clínica del Dolor Orofacial, el WHOQOL-bref y el cuestionario de dolor McGill. Todos los pacientes recibieron tratamiento periodontal. El grupo estudio presentó peor calidad de vida que el grupo control. No obstante, el Grupo de estudio mostró una tendencia de mejoría en la puntuación psicológica (p=0,06 ) y los descriptores afectivos en el cuestionario de dolor de McGill tambien mejoraron (p=0,014 ) después del tratamiento periodontal. No hubo cambios significativos en la calidad de vida de las evaluaciones pre y postoperatorias en ambos grupos (p>0,05). Concluimos que los pacientes de dolor crónico craneofaciales presentaron peor puntuación en el dominio físico y psicológico de la calidad de vida, sin embargo, hubo una mejoría en su estado psicológico 180 días después del tratamiento periodontal.

The aim of this study was to evaluate the periodontal condition and the metabolic control of patients with diabetes mellitus type 2. Patients with diabetes mellitus type 2 were evaluated pre- and post (30 days) treatment of the periodontitis through the following exams: glycemia, glycosylated hemoglobin, plaque index, gingival bleeding index and periodontal pocket depth index. Periodontal treatment consisted of: Scaling, root planning and plaque control, associated with systemic antibiotic therapy with amoxicillin. Seventeen patients (12 women and 5 men; mean age = 55.94 years) were included. The chief complaints were: gingival bleeding (n=13); gingival pain (n=8), tooth mobility (n=3), gingival swelling (n=2) and halitosis (n=2). The mean time of these complaints ranged from 2 months to 20 years. None of them had ever received guidance on oral hygiene or dental assessment. There was a reduction in the following indexes (30 days after the periodontal treatment): plaque, from 41.79±24% to 12.26±13%) (p0.0005), gingival bleeding from 51.58±25%) to 15.77±15% (p0.0005), periodontal pocket depth from 0.98±0.91 mm to 1.76±0.63 mm) (p0.0005). In 15 patients there was a reduction in the glycosylated hemoglobin (10.85±3.03% to 8.72±1.68%) (p0.0005). This preliminary study shows that patients of this sample had chronic and severe periodontal disease; there was a reduction in the glycosylated hemoglobin levels, but not of glycemia, 30 days after periodontal treatment. Long-standing studies are necessary; however patients with diabetes mellitus need control of chronic infections, including periodontal disease.

El objetivo fue evaluar la condición periodontal y el control metabólico de pacientes con diabetes mellitus tipo 2. En los pacientes con diabetes mellitus tipo 2 se evaluaron previo y posterior (30 días) al tratamiento de la periodontitis los siguientes exámenes: glucemia, hemoglobina glicosilada, índice de placa bacteriana, índice de sangrado gingival e índice de profundidad de la bolsa periodontal. El tratamiento periodontal consistió en: curetage, alisado radicular y control de placa, asociado a la terapia sistémica antibiótica con amoxicilina. Se evaluaron 17 pacientes (12 mujeres y 5 hombres, con una edad media de 55,94 años). Las principales complicaciones fueron: sangrado gingival (n= 13), dolor gingival (n= 8), movilidad dental (n= 3), edema gingival (n= 2) y halitosis (n= 2). El tiempo medio de estas complicaciones varió entre 2 meses y 20 años. Ninguno de ellos reconoció haber recibido orientación sobre higiene oral o evaluación dental. Hubo una reducción (30 días después del tratamiento periodontal) en los siguientes índices: placa, de 41,79±24% a 12,26±13%) (p0,0005); sangrado gingival, de 51,58±25%) a 15,77±15% (p0,0005), profundidad de la bolsa periodontal, de 0,98±0,91 mm a 1,76±0,63 mm) (p0,0005). En 15 pacientes se observó una reducción en la hemoglobina glucosilada (10,85±3,03% a 8,72±1,68%) (p0,0005). Observamos que los pacientes de esta muestra tenían enfermedad periodontal crónica y severa; que hubo una reducción en los niveles de hemoglobina glucosilada, pero no de la glucemia, 30 días después del tratamiento periodontal. Estudios longitudinales son necesarias, sin embargo los pacientes con diabetes mellitus requieren control de las infecciones crónicas, como la enfermedad periodontal.

Gengivite e periodontite são doenças periodontais imunoinflamatórias caracterizadas por infecções localizadas crônicas geralmente associadas a uma inflamação insidiosa. Essa revisão narrativa discute doenças periodontais e mecanismos que influenciam a resposta imune e a autoimunidade na área das doenças reumáticas pediátricas (DRP), particularmente a artrite idiopática juvenil (AIJ), lúpus eritematoso sistêmico juvenil (LESJ) e dermatomiosite juvenil (DMJ). Foi notada maior frequência de gengivite nessas doenças em comparação com controles sadios, enquanto casos de periodontite foram achados raros. Em pacientes com AIJ, a gengivite e a periodontite estavam relacionadas a fatores mecânicos, artrite crônica com incapacitação funcional, desregulação da resposta imunoinflamatória, dieta e medicamentos, principalmente corticosteroides e ciclosporina. Em pacientes com LESJ, a gengivite estava associada a períodos mais longos da doença, doses elevadas de corticosteroides, hiperativação dos linfócitos B e elevação da imunoglobulina G. São escassos os dados sobre doenças periodontais na população com DMJ; nos pacientes ativos, foi observado um padrão gengival singular, caracterizado por eritema gengival, dilatação dos capilares e formação arbustiforme. Em conclusão, gengivite foi a doença periodontal mais comum em pacientes com DRP. A associação observada com a atividade da doença reforça a necessidade de futuros estudos, com o intuito de determinar se a resolução dessa complicação irá influenciar o curso ou a gravidade da doença.

Gingivitis and periodontitis are immunoinflammatory periodontal diseases characterized by chronic localized infections usually associated with insidious inflammation. This narrative review discusses periodontal diseases and mechanisms influencing the immune response and autoimmunity in pediatric rheumatic diseases (PRD), particularly juvenile idiopathic arthritis (JIA), childhood-onset systemic lupus erythematosus (C-SLE) and juvenile dermatomyositis (JDM). Gingivitis was more frequently observed in these diseases compared to health controls, whereas periodontitis was a rare finding. In JIA patients, gingivitis and periodontitis were related to mechanical factors, chronic arthritis with functional disability, dysregulation of the immunoinflammatory response, diet and drugs, mainly corticosteroids and cyclosporine. In C-SLE, gingivitis was associated with longer disease period, high doses of corticosteroids, B-cell hyperactivation and immunoglobulin G elevation. There are scarce data on periodontal diseases in JDM population, and a unique gingival pattern, characterized by gingival erythema, capillary dilation and bush-loop formation, was observed in active patients. In conclusion, gingivitis was the most common periodontal disease in PRD. The observed association with disease activity reinforces the need for future studies to determine if resolution of this complication will influence disease course or severity.

OBJETIVO: A articulação temporomandibular é freqüentemente afetada pela artrite idiopática juvenil, e esta doença degenerativa, durante o crescimento facial, resulta em disfunção mandibular grave. No entanto, não há estudos que avaliam conjuntamente alterações na saúde oral (cáries e doenças gengivais) e na articulação temporomandibular decorrentes da artrite idiopática juvenil. O objetivo deste estudo é avaliar a condição dentária e a função mandibular de pacientes com artrite idiopática juvenil tratados em um hospital escola. MÉTODO: Trinta e seis pacientes com artrite idiopática juvenil (26 meninas e 10 meninos) foram submetidos a uma avaliação clínica sistemática de suas estruturas dentárias, orais e faciais (índice CPO-D, índice de placa e sangramento gengival, relação dentária, perfil facial e índice de Helkimo para articulação temporomandibular). O grupo controle foi composto por 13 crianças saudáveis. RESULTADOS: A média de idade dos pacientes com diagnóstico de artrite idiopática juvenil foi 10,8 anos; o perfil facial convexo foi encontrado em 12 pacientes com artrite idiopática juvenil e relação molar classe II esteve presente em 12 deles (p=0,032). Os índices de placa e sangramento gengival foram significantes em pacientes com artrite idiopática juvenil que apresentavam maior número de articulações dos membros superiores comprometidas (p=0,055). Mordida aberta anterior (cinco) e ruídos articulares (oito) foram encontradas no grupo com artrite idiopática juvenil . Este grupo apresentou 94% dos pacientes com disfunção da articulação temporomandibular (p=0,017), além de amplitude mandibular diminuída (p=0,0002) e mobilidade mandibular gravemente comprometida em 33% (p=0,015). CONCLUSÃO: Este estudo confirma que pacientes com artrite idiopática juvenil: a) têm alto índice de disfunção mandibular, que pode ser atribuído ao efeito direto da doença sobre a articulação temporomandibular e b) maior índice de doença gengival, que pode ser considerado como efeito indireto da artrite idiopática juvenil na saúde oral.

OBJECTIVE: It has been shown that the temporomandibular joint is frequently affected by juvenile idiopathic arthritis, and this degenerative disease, which may occur during facial growth, results in severe mandibular dysfunction. However, there are no studies that correlate oral health (tooth decay and gingival diseases) and temporomandibular joint dysfunction in patients with juvenile idiopathic arthritis. The aim of this study is to evaluate the oral and facial characteristics of the patients with juvenile idiopathic arthritis treated in a large teaching hospital. METHOD: Thirty-six patients with juvenile idiopathic arthritis (26 female and 10 male) underwent a systematic clinical evaluation of their dental, oral, and facial structures (DMFT index, plaque and gingival bleeding index, dental relationship, facial profile, and Helkimo's index). The control group was composed of 13 healthy children. RESULTS: The mean age of the patients with juvenile idiopathic arthritis was 10.8 years; convex facial profile was present in 12 juvenile idiopathic arthritis patients, and class II molar relation was present in 12 (P = .032). The indexes of plaque and gingival bleeding were significant in juvenile idiopathic arthritis patients with a higher number of superior limbs joints involved (P = .055). Anterior open bite (5) and temporomandibular joint noise (8) were present in the juvenile idiopathic arthritis group. Of the group in this sample, 94% (P = .017) had temporomandibular joint dysfunction, 80% had decreased mandibular opening (P = 0.0002), and mandibular mobility was severely impaired in 33% (P = .015). CONCLUSION: This study confirms that patients with juvenile idiopathic arthritis a) have a high incidence of mandibular dysfunction that can be attributed to the direct effect of the disease in the temporomandibular joint and b) have a higher incidence of gingival disease that can be considered a secondary effect of juvenile idiopathic arthritis on oral health.